- Sandwich Shop Restaurants, Janesville
- Satellite Dish Antennas & Equipment Dealers, Janesville
- Satellite TV Service, Janesville
- School Bus Transportation Service, Janesville
- Scrap & Waste Materials, Janesville
- Screen Printing, Janesville
- Secondary Schools, Janesville
- Sheet Metal, Janesville
- Sheet Metal Contractors, Janesville - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Janesville
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- Shopping & Shopping Services, Janesville
- Siding Contractors, Janesville - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Social Services & Welfare, Janesville
- Specialty Animal Services, Janesville
- Specialty Stores, Janesville
- Sporting & Recreational Camps, Janesville
- Sports & Recreational Services, Janesville
- Spraying Booths & Equipment, Janesville
- Storage Containers, Janesville
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