- Sand Gravel & Aggregate, Pipestone
- Sandwich Shop Restaurants, Pipestone
- Satellite TV Service, Pipestone
- Sealcoating, Pipestone - Asphalt Sealcoating & Paving
- Security Brokers & Dealers, Pipestone
- Senior Citizens Service & Health Organizations, Pipestone
- Sheriff's Department, Pipestone
- Shopping & Shopping Services, Pipestone
- Social Services & Welfare, Pipestone
- Special Education & Care, Pipestone
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